Product Addition - In need of an anti-rat/mouse transferrin receptor antibody?

來源: BioXcell   2020-3-25   訪問量:364評論(0)

Rectangle: Rounded Corners: Product References

Rectangle: Rounded Corners: Shop anti-rat/mouse CD71

InVivoMAb anti-rat/mouse CD71 (TfR1)

Useful for targeted drug delivery to the brain

The OX-26 monoclonal antibody reacts with rat CD71 also known as transferrin receptor protein 1 (TfR1). The antibody is reported to cross-react with mouse CD71 as well. CD71 is a 170-180 kDa type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. CD71 plays a role in the control of cellular proliferation and is required for iron import from transferrin into cells by endocytosis. CD71 is expressed on malignant cells at high levels and its expression correlates with cancer progression. This high expression on malignant cells along with CD71’s ability to internalize and the necessity of iron for cancer cell proliferation makes the transferrin receptor an attractive target to exploit for the delivery of drugs into malignant cells. Upon binding to an extracellular domain of CD71, OX-26 is transferred into the blood-brain barrier (BBB) via the endogenous transferrin transport system. Under this mechanism, the OX-26 antibody is often used to transport conjugated drugs across the BBB in experimental rat models.

This Antibody Is Useful For:

  • Targeted drug delivery to the brain
  • Immunohistochemistry (frozen)
  • Flow cytometry

As always Bio X Cell antibodies are specifically formulated for in vivo use and feature:

  • 95% purity
  • Ultra-low endotoxin levels
  • Preservative, stabilizer, and carrier protein-free

Don’t forget to add the recommended isotype control antibody and dilution buffer.

Rectangle: Rounded Corners: SHOP mouse IgG2a

Rectangle: Rounded Corners: SHOP pH 7.0 Dilution Buffer



BioXcell   商家主頁

地址:10 Technology Dr., Suite 2B, West Lebanon
聯系人:BioXcell
電話:0016032988564
傳真:
Email:customerservice@bxcell.com

河南福彩网-首页_欢迎您 中方县 | 永清县 | 开封市 | 莱西市 | 洛浦县 | 通渭县 | 博客 | 关岭 | 京山县 | 左云县 | 太仓市 | 黄骅市 | 方山县 | 通道 | 晋城 | 祁门县 | 封丘县 | 黄山市 | 隆安县 | 长葛市 | 平安县 | 陆良县 |